Adaptive -Cell Proliferation Is Severely Restricted With Advanced Age
نویسندگان
چکیده
منابع مشابه
Adaptive Beta Cell Proliferation Is Severely Restricted with Advanced Age
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
متن کاملAdaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
OBJECTIVE Regeneration of the insulin-secreting beta-cells is a fundamental research goal that could benefit patients with either type 1 or type 2 diabetes. beta-Cell proliferation can be acutely stimulated by a variety of stimuli in young rodents. However, it is unknown whether this adaptive beta-cell regeneration capacity is retained into old age. RESEARCH DESIGN AND METHODS We assessed ada...
متن کاملAdvanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock
INTRODUCTION We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock. METHODS We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. RESULTS We found that there was no difference in injury se...
متن کاملadvanced maternal age relationship with pregnancy complications
background: due to increase in pregnancy complications in advanced age, this study was conducted to assess the relationship between advanced maternal age and the pregnancy complications. methods: pregnant women who admitted to the motazedi hospital in kermanshah were included in this analytic–cross sectional study. the study group was 1178 cases that divided into two sub-groups; 35-40 year-old ...
متن کاملAdvanced paternal age is associated with lower facial attractiveness
a r t i c l e i n f o In view of disease risk, Kong et al. (2012) demonstrated that most of the new mutations are explained by the age of the father at conception. Accordingly, paternal age effects have been found for a variety of offspring traits, from physical and mental health to intelligence. Here, we investigated whether facial attractiveness is significantly associated with paternal age. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-1198